BRCA2-dependent homologous recombination is required for repair of Arsenite-induced replication lesions in mammalian cells

Arsenic exposure constitutes one of the most widespread environmental carcinogens, and is associated with increased risk of many different types of cancers. Here we report that arsenite (As[III]) can induce both replication-dependent DNA double-strand breaks (DSB) and homologous recombination (HR) a...

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Detalles Bibliográficos
Autores principales: Ying, Songmin, Myers, Katie, Bottomley, Sarah, Helleday, Thomas, Bryant, Helen E.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731915/
https://www.ncbi.nlm.nih.gov/pubmed/19553191
http://dx.doi.org/10.1093/nar/gkp538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731915/
https://www.ncbi.nlm.nih.gov/pubmed/19553191
http://dx.doi.org/10.1093/nar/gkp538

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