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BRCA2-dependent homologous recombination is required for repair of Arsenite-induced replication lesions in mammalian cells
Arsenic exposure constitutes one of the most widespread environmental carcinogens, and is associated with increased risk of many different types of cancers. Here we report that arsenite (As[III]) can induce both replication-dependent DNA double-strand breaks (DSB) and homologous recombination (HR) a...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731915/ https://www.ncbi.nlm.nih.gov/pubmed/19553191 http://dx.doi.org/10.1093/nar/gkp538 |