Hypoxia and TGF-β Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Cells and the Bone Microenvironment

BACKGROUND: Most patients with advanced breast cancer develop bone metastases, which cause pain, hypercalcemia, fractures, nerve compression and paralysis. Chemotherapy causes further bone loss, and bone-specific treatments are only palliative. Multiple tumor-secreted factors act on the bone microen...

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Detalles Bibliográficos
Autores principales: Dunn, Lauren K., Mohammad, Khalid S., Fournier, Pierrick G. J., McKenna, C. Ryan, Davis, Holly W., Niewolna, Maria, Peng, Xiang Hong, Chirgwin, John M., Guise, Theresa A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731927/
https://www.ncbi.nlm.nih.gov/pubmed/19727403
http://dx.doi.org/10.1371/journal.pone.0006896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731927/
https://www.ncbi.nlm.nih.gov/pubmed/19727403
http://dx.doi.org/10.1371/journal.pone.0006896

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