Functionally Relevant Domains of the Prion Protein Identified In Vivo

The prion consists essentially of PrP(Sc), a misfolded and aggregated conformer of the cellular protein PrP(C). Whereas PrP(C) deficient mice are clinically healthy, expression of PrP(C) variants lacking its central domain (PrP(ΔCD)), or of the PrP-related protein Dpl, induces lethal neurodegenerati...

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Detalles Bibliográficos
Autores principales: Baumann, Frank, Pahnke, Jens, Radovanovic, Ivan, Rülicke, Thomas, Bremer, Juliane, Tolnay, Markus, Aguzzi, Adriano
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733036/
https://www.ncbi.nlm.nih.gov/pubmed/19738901
http://dx.doi.org/10.1371/journal.pone.0006707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733036/
https://www.ncbi.nlm.nih.gov/pubmed/19738901
http://dx.doi.org/10.1371/journal.pone.0006707

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