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Functionally Relevant Domains of the Prion Protein Identified In Vivo
The prion consists essentially of PrP(Sc), a misfolded and aggregated conformer of the cellular protein PrP(C). Whereas PrP(C) deficient mice are clinically healthy, expression of PrP(C) variants lacking its central domain (PrP(ΔCD)), or of the PrP-related protein Dpl, induces lethal neurodegenerati...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733036/ https://www.ncbi.nlm.nih.gov/pubmed/19738901 http://dx.doi.org/10.1371/journal.pone.0006707 |