Pharmacodynamic Modeling of Acute and Chronic Effects of Methylprednisolone on Hepatic Urea Cycle Genes in Rats

Corticosteroids (CS) regulate many enzymes at both mRNA and protein levels. This study used microarrays to broadly assess regulation of various genes related to the greater urea cycle and employs pharmacokinetic/pharmacodynamic (PK/PD) modeling to quantitatively analyze and compare the temporal prof...

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Detalles Bibliográficos
Autores principales: Hazra, Anasuya, DuBois, Debra C., Almon, Richard R., Snyder, Grayson H., Jusko, William J.
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2008
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733100/
https://www.ncbi.nlm.nih.gov/pubmed/19787073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733100/
https://www.ncbi.nlm.nih.gov/pubmed/19787073

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