Crystal structure of the complete integrin αVβ3 ectodomain plus an α/β transmembrane fragment

We determined the crystal structure of 1TM-αVβ3, which represents the complete unconstrained ectodomain plus short C-terminal transmembrane stretches of the αV and β3 subunits. 1TM-αVβ3 is more compact and less active in solution when compared with ΔTM-αVβ3, which lacks the short C-terminal stretche...

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Detalles Bibliográficos
Autores principales: Xiong, Jian-Ping, Mahalingham, Bhuvaneshwari, Alonso, Jose Luis, Borrelli, Laura Ann, Rui, Xianliang, Anand, Saurabh, Hyman, Bradley T., Rysiok, Thomas, Müller-Pompalla, Dirk, Goodman, Simon L., Arnaout, M. Amin
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733745/
https://www.ncbi.nlm.nih.gov/pubmed/19704023
http://dx.doi.org/10.1083/jcb.200905085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733745/
https://www.ncbi.nlm.nih.gov/pubmed/19704023
http://dx.doi.org/10.1083/jcb.200905085

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