Posterior Malformations in Dact1 mutant mice arise through misregulated Vangl2 at the Primitive Streak

Mice homozygous for mutations in Dact1 (Dpr/Frodo) phenocopy human malformations involving the spine, genitourinary system, and distal digestive tract. We trace this phenotype to disrupted germ layer morphogenesis at the primitive streak (PS). Remarkably, heterozygous mutation of Vangl2, a transmemb...

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Detalles Bibliográficos
Autores principales: Suriben, Rowena, Kivimäe, Saul, Fisher, Daniel A., Moon, Randall T., Cheyette, Benjamin N.R.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733921/
https://www.ncbi.nlm.nih.gov/pubmed/19701191
http://dx.doi.org/10.1038/ng.435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733921/
https://www.ncbi.nlm.nih.gov/pubmed/19701191
http://dx.doi.org/10.1038/ng.435

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