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Posterior Malformations in Dact1 mutant mice arise through misregulated Vangl2 at the Primitive Streak
Mice homozygous for mutations in Dact1 (Dpr/Frodo) phenocopy human malformations involving the spine, genitourinary system, and distal digestive tract. We trace this phenotype to disrupted germ layer morphogenesis at the primitive streak (PS). Remarkably, heterozygous mutation of Vangl2, a transmemb...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733921/ https://www.ncbi.nlm.nih.gov/pubmed/19701191 http://dx.doi.org/10.1038/ng.435 |