BMI1 Cooperates with H-RAS to Induce an Aggressive Breast Cancer Phenotype with Brain Metastases

BMI1 is a member of the polycomb group of transcription repressors that functions in stem cell maintenance and oncogenesis through inhibition of the INK4A/ARF tumour suppressor locus. Overexpression of BMI1 is associated with poor prognosis in several human cancers, including breast cancer. We have...

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Detalles Bibliográficos
Autores principales: Hoenerhoff, Mark J., Chu, Isabel, Barkan, Dalit, Liu, Zi-yao, Datta, Sonal, Dimri, Goberdhan P., Green, Jeffery E.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733922/
https://www.ncbi.nlm.nih.gov/pubmed/19543317
http://dx.doi.org/10.1038/onc.2009.165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733922/
https://www.ncbi.nlm.nih.gov/pubmed/19543317
http://dx.doi.org/10.1038/onc.2009.165

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