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BMI1 Cooperates with H-RAS to Induce an Aggressive Breast Cancer Phenotype with Brain Metastases
BMI1 is a member of the polycomb group of transcription repressors that functions in stem cell maintenance and oncogenesis through inhibition of the INK4A/ARF tumour suppressor locus. Overexpression of BMI1 is associated with poor prognosis in several human cancers, including breast cancer. We have...
Autores principales: | Hoenerhoff, Mark J., Chu, Isabel, Barkan, Dalit, Liu, Zi-yao, Datta, Sonal, Dimri, Goberdhan P., Green, Jeffery E. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733922/ https://www.ncbi.nlm.nih.gov/pubmed/19543317 http://dx.doi.org/10.1038/onc.2009.165 |
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