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LRP1 Regulates Architecture of the Vascular Wall by Controlling PDGFRβ-Dependent Phosphatidylinositol 3-Kinase Activation

BACKGROUND: Low density lipoprotein receptor-related protein 1 (LRP1) protects against atherosclerosis by regulating the activation of platelet-derived growth factor receptor β (PDGFRβ) in vascular smooth muscle cells (SMCs). Activated PDGFRβ undergoes tyrosine phosphorylation and subsequently inter...

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Detalles Bibliográficos
Autores principales: Zhou, Li, Takayama, Yoshiharu, Boucher, Philippe, Tallquist, Michelle D., Herz, Joachim
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734324/
https://www.ncbi.nlm.nih.gov/pubmed/19742316
http://dx.doi.org/10.1371/journal.pone.0006922