Antisense gapmers selectively suppress individual oncogenic p73 splice isoforms and inhibit tumor growth in vivo

BACKGROUND: Differential mRNA splicing and alternative promoter usage of the TP73 gene results in the expression of multiple NH2-truncated isoforms that act as oncogenes. Abundant levels of these p73 variants in a variety of human cancers correlated with adverse clinical prognosis and response failu...

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Detalles Bibliográficos
Autores principales: Emmrich, Stephan, Wang, Weiwei, John, Katja, Li, Wenzhong, Pützer, Brigitte M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734544/
https://www.ncbi.nlm.nih.gov/pubmed/19671150
http://dx.doi.org/10.1186/1476-4598-8-61

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734544/
https://www.ncbi.nlm.nih.gov/pubmed/19671150
http://dx.doi.org/10.1186/1476-4598-8-61

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