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Editing of Serotonin 2C Receptor mRNA in the Prefrontal Cortex Characterizes High Novelty Locomotor Response Behavioral Trait

Serotonin 2C receptor (5-HT(2C)R) exerts a major inhibitory influence on dopamine (DA) neurotransmission within the mesocorticolimbic DA pathway that is implicated in drug reward and goal-directed behaviors. 5-HT(2C)R pre-mRNA undergoes adenosine-to-inosine editing generating numerous receptor isofo...

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Detalles Bibliográficos
Autores principales: Dracheva, Stella, Lyddon, Rebecca, Barley, Kevin, Marcus, Sue M., Hurd, Yasmin L., Byne, William M.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735076/
https://www.ncbi.nlm.nih.gov/pubmed/19494808
http://dx.doi.org/10.1038/npp.2009.51