d-Psicose Inhibits Intestinal α-Glucosidase and Suppresses the Glycemic Response after Ingestion of Carbohydrates in Rats

d-psicose is one of the rare sugars present in small quantities in commercial carbohydrates and agricultural products. In this study, we investigated the effects of d-psicose on the activities of α-amylases and α-glucosidases in vitro, and evaluated the effects of d-psicose on the in vivo postprandi...

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Autores principales: Matsuo, Tatsuhiro, Izumori, Ken
Formato: Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735633/
https://www.ncbi.nlm.nih.gov/pubmed/19794929
http://dx.doi.org/10.3164/jcbn.09-36
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author Matsuo, Tatsuhiro
Izumori, Ken
author_facet Matsuo, Tatsuhiro
Izumori, Ken
author_sort Matsuo, Tatsuhiro
collection PubMed
description d-psicose is one of the rare sugars present in small quantities in commercial carbohydrates and agricultural products. In this study, we investigated the effects of d-psicose on the activities of α-amylases and α-glucosidases in vitro, and evaluated the effects of d-psicose on the in vivo postprandial glycemic response using rats. In the in vitro study, d-psicose potently inhibited the intestinal sucrase and maltase, however, slightly inhibited the intestinal and salivary α-amylase activities. Male Wistar rats (6 months old) were administrated 2 g/kg of sucrose, maltose or soluble starch together with 0.2 g/kg of d-psicose or d-fructose. The d-psicose significantly inhibited the increment of plasma glucose concentration induced by sucrose or maltose. The starch-induced glycemic response tended to be suppressed by d-psicose, however the suppression was not significant. These results suggest that d-psicose inhibits intestinal sucrase and maltase activities and suppresses the plasma glucose increase the normally occurs after sucrose and maltose ingestion. Thus, d-psicose may be useful in preventing postprandial hyperglycemia in diabetic patients when foods containing sucrose and maltose are ingested.
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spelling pubmed-27356332009-09-30 d-Psicose Inhibits Intestinal α-Glucosidase and Suppresses the Glycemic Response after Ingestion of Carbohydrates in Rats Matsuo, Tatsuhiro Izumori, Ken J Clin Biochem Nutr Original Article d-psicose is one of the rare sugars present in small quantities in commercial carbohydrates and agricultural products. In this study, we investigated the effects of d-psicose on the activities of α-amylases and α-glucosidases in vitro, and evaluated the effects of d-psicose on the in vivo postprandial glycemic response using rats. In the in vitro study, d-psicose potently inhibited the intestinal sucrase and maltase, however, slightly inhibited the intestinal and salivary α-amylase activities. Male Wistar rats (6 months old) were administrated 2 g/kg of sucrose, maltose or soluble starch together with 0.2 g/kg of d-psicose or d-fructose. The d-psicose significantly inhibited the increment of plasma glucose concentration induced by sucrose or maltose. The starch-induced glycemic response tended to be suppressed by d-psicose, however the suppression was not significant. These results suggest that d-psicose inhibits intestinal sucrase and maltase activities and suppresses the plasma glucose increase the normally occurs after sucrose and maltose ingestion. Thus, d-psicose may be useful in preventing postprandial hyperglycemia in diabetic patients when foods containing sucrose and maltose are ingested. the Society for Free Radical Research Japan 2009-09 2009-08-28 /pmc/articles/PMC2735633/ /pubmed/19794929 http://dx.doi.org/10.3164/jcbn.09-36 Text en Copyright © 2009 JCBN This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Matsuo, Tatsuhiro
Izumori, Ken
d-Psicose Inhibits Intestinal α-Glucosidase and Suppresses the Glycemic Response after Ingestion of Carbohydrates in Rats
title d-Psicose Inhibits Intestinal α-Glucosidase and Suppresses the Glycemic Response after Ingestion of Carbohydrates in Rats
title_full d-Psicose Inhibits Intestinal α-Glucosidase and Suppresses the Glycemic Response after Ingestion of Carbohydrates in Rats
title_fullStr d-Psicose Inhibits Intestinal α-Glucosidase and Suppresses the Glycemic Response after Ingestion of Carbohydrates in Rats
title_full_unstemmed d-Psicose Inhibits Intestinal α-Glucosidase and Suppresses the Glycemic Response after Ingestion of Carbohydrates in Rats
title_short d-Psicose Inhibits Intestinal α-Glucosidase and Suppresses the Glycemic Response after Ingestion of Carbohydrates in Rats
title_sort d-psicose inhibits intestinal α-glucosidase and suppresses the glycemic response after ingestion of carbohydrates in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735633/
https://www.ncbi.nlm.nih.gov/pubmed/19794929
http://dx.doi.org/10.3164/jcbn.09-36
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AT izumoriken dpsicoseinhibitsintestinalaglucosidaseandsuppressestheglycemicresponseafteringestionofcarbohydratesinrats