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Searching for Factors that Distinguish Disease-Prone and Disease-Resistant Prions via Sequence Analysis
The exact mechanisms of prion misfolding and factors that predispose an individual to prion diseases are largely unknown. Our approach to identifying candidate factors in-silico relies on contrasting the C-terminal domain of PrP(C) sequences from two groups of vertebrate species: those that have bee...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Libertas Academica
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735959/ https://www.ncbi.nlm.nih.gov/pubmed/19812771 |