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Overexpression of thioredoxin in islets transduced by a lentiviral vector prolongs graft survival in autoimmune diabetic NOD mice

ABSTRACT: Pancreatic islet transplantation is considered an appropriate treatment to achieve insulin independence in type I diabetic patients. However, islet isolation and transplantation-induced oxidative stress and autoimmune-mediated destruction are still the major obstacles to the long-term surv...

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Detalles Bibliográficos
Autores principales: Chou, Feng-Cheng, Sytwu, Huey-Kang
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736160/
https://www.ncbi.nlm.nih.gov/pubmed/19671194
http://dx.doi.org/10.1186/1423-0127-16-71