Early Steps of HIV-1 Fusion Define the Sensitivity to Inhibitory Peptides That Block 6-Helix Bundle Formation

The HIV envelope (Env) glycoprotein mediates membrane fusion through sequential interactions with CD4 and coreceptors, followed by the refolding of the transmembrane gp41 subunit into the stable 6-helix bundle (6HB) conformation. Synthetic peptides derived from the gp41 C-terminal heptad repeat doma...

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Detalles Bibliográficos
Autores principales: Miyauchi, Kosuke, Kozlov, Michael M., Melikyan, Gregory B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736578/
https://www.ncbi.nlm.nih.gov/pubmed/19763181
http://dx.doi.org/10.1371/journal.ppat.1000585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736578/
https://www.ncbi.nlm.nih.gov/pubmed/19763181
http://dx.doi.org/10.1371/journal.ppat.1000585

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