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From bending DNA to diabetes: the curious case of HMGA1
Although mice lacking the architectural DNA binding factor HMGA1 are diabetic and express very low levels of the insulin receptor, they have increased insulin sensitivity. A study in BMC Biology now suggests that changes in circulating retinol binding protein partly account for this paradox.
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736670/ https://www.ncbi.nlm.nih.gov/pubmed/19664187 http://dx.doi.org/10.1186/jbiol164 |