From bending DNA to diabetes: the curious case of HMGA1

Although mice lacking the architectural DNA binding factor HMGA1 are diabetic and express very low levels of the insulin receptor, they have increased insulin sensitivity. A study in BMC Biology now suggests that changes in circulating retinol binding protein partly account for this paradox.

Detalles Bibliográficos
Autor principal: Semple, Robert K
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736670/
https://www.ncbi.nlm.nih.gov/pubmed/19664187
http://dx.doi.org/10.1186/jbiol164
Descripción
Sumario:Although mice lacking the architectural DNA binding factor HMGA1 are diabetic and express very low levels of the insulin receptor, they have increased insulin sensitivity. A study in BMC Biology now suggests that changes in circulating retinol binding protein partly account for this paradox.

Ejemplares similares