Cargando…
From bending DNA to diabetes: the curious case of HMGA1
Although mice lacking the architectural DNA binding factor HMGA1 are diabetic and express very low levels of the insulin receptor, they have increased insulin sensitivity. A study in BMC Biology now suggests that changes in circulating retinol binding protein partly account for this paradox.
| Autor principal: | |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736670/ https://www.ncbi.nlm.nih.gov/pubmed/19664187 http://dx.doi.org/10.1186/jbiol164 |
| _version_ | 1782171357440638976 |
|---|---|
| author | Semple, Robert K |
| author_facet | Semple, Robert K |
| author_sort | Semple, Robert K |
| collection | PubMed |
| description | Although mice lacking the architectural DNA binding factor HMGA1 are diabetic and express very low levels of the insulin receptor, they have increased insulin sensitivity. A study in BMC Biology now suggests that changes in circulating retinol binding protein partly account for this paradox. |
| format | Text |
| id | pubmed-2736670 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2009 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-27366702010-01-27 From bending DNA to diabetes: the curious case of HMGA1 Semple, Robert K J Biol Minireview Although mice lacking the architectural DNA binding factor HMGA1 are diabetic and express very low levels of the insulin receptor, they have increased insulin sensitivity. A study in BMC Biology now suggests that changes in circulating retinol binding protein partly account for this paradox. BioMed Central 2009 2009-07-27 /pmc/articles/PMC2736670/ /pubmed/19664187 http://dx.doi.org/10.1186/jbiol164 Text en Copyright ©2009 BioMed Central Ltd. |
| spellingShingle | Minireview Semple, Robert K From bending DNA to diabetes: the curious case of HMGA1 |
| title | From bending DNA to diabetes: the curious case of HMGA1 |
| title_full | From bending DNA to diabetes: the curious case of HMGA1 |
| title_fullStr | From bending DNA to diabetes: the curious case of HMGA1 |
| title_full_unstemmed | From bending DNA to diabetes: the curious case of HMGA1 |
| title_short | From bending DNA to diabetes: the curious case of HMGA1 |
| title_sort | from bending dna to diabetes: the curious case of hmga1 |
| topic | Minireview |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736670/ https://www.ncbi.nlm.nih.gov/pubmed/19664187 http://dx.doi.org/10.1186/jbiol164 |
| work_keys_str_mv | AT semplerobertk frombendingdnatodiabetesthecuriouscaseofhmga1 |