MI-63: A novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wild-type p53

BACKGROUND: Interruption of the role of p53s as a tumour suppressor by MDM2 may be one of the mechanisms by which cancer cells evade current therapy. Blocking the inhibition of wild-type p53 by MDM2 in cancer cells should reactivate p53's tumour suppressor functions and enhance current cancer t...

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Detalles Bibliográficos
Autores principales: Canner, J A, Sobo, M, Ball, S, Hutzen, B, DeAngelis, S, Willis, W, Studebaker, A W, Ding, K, Wang, S, Yang, D, Lin, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736841/
https://www.ncbi.nlm.nih.gov/pubmed/19707204
http://dx.doi.org/10.1038/sj.bjc.6605199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736841/
https://www.ncbi.nlm.nih.gov/pubmed/19707204
http://dx.doi.org/10.1038/sj.bjc.6605199

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