Efficient production of human bivalent and trivalent anti-MUC1 Fab-scFv antibodies in Pichia pastoris

BACKGROUND: Tumour associated antigens on the surface of tumour cells, such as MUC1, are being used as specific antibody targets for immunotherapy of human malignancies. In order to address the poor penetration of full sized monoclonal antibodies in tumours, intermediate sized antibodies are being d...

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Detalles Bibliográficos
Autores principales: Schoonooghe, Steve, Kaigorodov, Vladimir, Zawisza, Monika, Dumolyn, Caroline, Haustraete, Jurgen, Grooten, Johan, Mertens, Nico
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736937/
https://www.ncbi.nlm.nih.gov/pubmed/19671134
http://dx.doi.org/10.1186/1472-6750-9-70

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736937/
https://www.ncbi.nlm.nih.gov/pubmed/19671134
http://dx.doi.org/10.1186/1472-6750-9-70

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