Protease inhibitor-induced nausea and vomiting is attenuated by a peripherally acting, opioid-receptor antagonist in a rat model

BACKGROUND: Protease inhibitors such as ritonavir can cause nausea and vomiting which is the most common reason for discontinuation. Rats react to nauseous and emetic stimuli by increasing their oral intake of non-nutritive substances like kaolin, known as pica behavior. In this study, we evaluated...

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Detalles Bibliográficos
Autores principales: Yuan, Chun-Su, Wang, Chong-Zhi, Mehendale, Sangeeta R, Aung, Han H, Foo, Adela, Israel, Robert J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736972/
https://www.ncbi.nlm.nih.gov/pubmed/19698111
http://dx.doi.org/10.1186/1742-6405-6-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736972/
https://www.ncbi.nlm.nih.gov/pubmed/19698111
http://dx.doi.org/10.1186/1742-6405-6-19

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