Population Pharmacokinetic Model of the Pregabalin-Sildenafil Interaction in Rats: Application of Simulation to Preclinical PK-PD Study Design

PURPOSE: Preliminary evidence has suggested a synergistic interaction between pregabalin and sildenafil for the treatment of neuropathic pain. The focus of this study was to determine the influence of sildenafil on the pharmacokinetics (PK) of pregabalin with the objective of informing the design of...

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Detalles Bibliográficos
Autores principales: Bender, Gregor, Gosset, James, Florian, Jeff, Tan, Keith, Field, Mark, Marshall, Scott, DeJongh, Joost, Bies, Robert, Danhof, Meindert
Formato: Texto
Lenguaje:English
Publicado: Springer US 2009
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737110/
https://www.ncbi.nlm.nih.gov/pubmed/19669867
http://dx.doi.org/10.1007/s11095-009-9942-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737110/
https://www.ncbi.nlm.nih.gov/pubmed/19669867
http://dx.doi.org/10.1007/s11095-009-9942-y

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