Augmented TLR9-induced Btk activation in PIR-B–deficient B-1 cells provokes excessive autoantibody production and autoimmunity

Pathogens are sensed by Toll-like receptors (TLRs) expressed in leukocytes in the innate immune system. However, excess stimulation of TLR pathways is supposed to be connected with provocation of autoimmunity. We show that paired immunoglobulin (Ig)-like receptor B (PIR-B), an immunoreceptor tyrosin...

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Detalles Bibliográficos
Autores principales: Kubo, Tomohiro, Uchida, Yuki, Watanabe, Yuko, Abe, Masahiro, Nakamura, Akira, Ono, Masao, Akira, Shizuo, Takai, Toshiyuki
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737165/
https://www.ncbi.nlm.nih.gov/pubmed/19687229
http://dx.doi.org/10.1084/jem.20082392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737165/
https://www.ncbi.nlm.nih.gov/pubmed/19687229
http://dx.doi.org/10.1084/jem.20082392

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