Selective cleavage of AChR cRNAs harbouring mutations underlying the slow channel myasthenic syndrome by hammerhead ribozymes

Slow channel congenital myasthenic syndrome (SCCMS) is a dominant disorder caused by missense mutations in muscle acetylcholine receptors (AChR). Expression from mutant alleles causes prolonged AChR ion-channel activations. This ‘gain of function’ results in excitotoxic damage due to excess entry of...

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Detalles Bibliográficos
Autores principales: Abdelgany, Amr, Ealing, John, Wood, Matthew, Beeson, David
Formato: Texto
Lenguaje:English
Publicado: Library Publishing Media 2005
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737193/
https://www.ncbi.nlm.nih.gov/pubmed/19771201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737193/
https://www.ncbi.nlm.nih.gov/pubmed/19771201

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