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Mechanisms of RNAi: mRNA cleavage fragments may indicate stalled RISC
The molecular mechanism of RNA interference (RNAi) is under intense investigation. We previously demonstrated the existence of inactive siRNAs and also of mRNA cleavage in vivo in human cells. Here it is shown that some siRNAs with low activity leave mRNA cleavage fragments while an siRNA with highe...
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| Formato: | Texto |
| Lenguaje: | English |
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Library Publishing Media
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737194/ https://www.ncbi.nlm.nih.gov/pubmed/19771200 |