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Distinct subdomains of the KCNQ1 S6 segment determine channel modulation by different KCNE subunits

Modulation of voltage-gated potassium (K(V)) channels by the KCNE family of single transmembrane proteins has physiological and pathophysiological importance. All five KCNE proteins (KCNE1–KCNE5) have been demonstrated to modulate heterologously expressed KCNQ1 (K(V)7.1) with diverse effects, making...

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Detalles Bibliográficos
Autores principales: Vanoye, Carlos G., Welch, Richard C., Daniels, Melissa A., Manderfield, Lauren J., Tapper, Andrew R., Sanders, Charles R., George, Alfred L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737226/
https://www.ncbi.nlm.nih.gov/pubmed/19687231
http://dx.doi.org/10.1085/jgp.200910234