On the Origins of Enzyme Inhibitor Selectivity and Promiscuity: A Case Study of Protein Kinase Binding to Staurosporine

Relationships between ligand binding and the shapes of the binding sites in families of homologous enzymes are investigated by comparing matrices of distances between key binding site atoms. Multiple linear regression is used to help identify key distances that influence ligand binding affinity. In...

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Detalles Bibliográficos
Autores principales: Tanramluk, Duangrudee, Schreyer, Adrian, Pitt, William R, Blundell, Tom L
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737611/
https://www.ncbi.nlm.nih.gov/pubmed/19519740
http://dx.doi.org/10.1111/j.1747-0285.2009.00832.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737611/
https://www.ncbi.nlm.nih.gov/pubmed/19519740
http://dx.doi.org/10.1111/j.1747-0285.2009.00832.x

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