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Does negative auto-regulation increase gene duplicability?

BACKGROUND: A prerequisite for a duplication to spread through and persist in a given population is retaining expression of both gene copies. Yet changing a gene's dosage is frequently detrimental to fitness. Consequently, dosage-sensitive genes are less likely to duplicate. However, in cases w...

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Detalles Bibliográficos
Autores principales: Warnecke, Tobias, Wang, Guang-Zhong, Lercher, Martin J, Hurst, Laurence D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739200/
https://www.ncbi.nlm.nih.gov/pubmed/19664220
http://dx.doi.org/10.1186/1471-2148-9-193