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Does negative auto-regulation increase gene duplicability?
BACKGROUND: A prerequisite for a duplication to spread through and persist in a given population is retaining expression of both gene copies. Yet changing a gene's dosage is frequently detrimental to fitness. Consequently, dosage-sensitive genes are less likely to duplicate. However, in cases w...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739200/ https://www.ncbi.nlm.nih.gov/pubmed/19664220 http://dx.doi.org/10.1186/1471-2148-9-193 |
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author | Warnecke, Tobias Wang, Guang-Zhong Lercher, Martin J Hurst, Laurence D |
author_facet | Warnecke, Tobias Wang, Guang-Zhong Lercher, Martin J Hurst, Laurence D |
author_sort | Warnecke, Tobias |
collection | PubMed |
description | BACKGROUND: A prerequisite for a duplication to spread through and persist in a given population is retaining expression of both gene copies. Yet changing a gene's dosage is frequently detrimental to fitness. Consequently, dosage-sensitive genes are less likely to duplicate. However, in cases where the level of gene product is controlled, via negative feedback, by its own abundance, an increase in gene copy number can in principle be decoupled from an increase in protein while both copies remain expressed. Using data from the transcriptional networks of E. coli and S. cerevisiae, we test the hypothesis that genes under negative auto-regulation show enhanced duplicability. RESULTS: Controlling for several known correlates of duplicability, we find no statistically significant support in either E. coli or S. cerevisiae that transcription factors under negative auto-regulation hold a duplicability advantage over transcription factors with no auto-regulation. CONCLUSION: Based on the analysis of transcriptional networks in E. coli and S. cerevisiae, there is no evidence that negative auto-regulation has contributed, on a genome-wide scale, to the variability in gene family sizes in these species. |
format | Text |
id | pubmed-2739200 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-27392002009-09-08 Does negative auto-regulation increase gene duplicability? Warnecke, Tobias Wang, Guang-Zhong Lercher, Martin J Hurst, Laurence D BMC Evol Biol Research Article BACKGROUND: A prerequisite for a duplication to spread through and persist in a given population is retaining expression of both gene copies. Yet changing a gene's dosage is frequently detrimental to fitness. Consequently, dosage-sensitive genes are less likely to duplicate. However, in cases where the level of gene product is controlled, via negative feedback, by its own abundance, an increase in gene copy number can in principle be decoupled from an increase in protein while both copies remain expressed. Using data from the transcriptional networks of E. coli and S. cerevisiae, we test the hypothesis that genes under negative auto-regulation show enhanced duplicability. RESULTS: Controlling for several known correlates of duplicability, we find no statistically significant support in either E. coli or S. cerevisiae that transcription factors under negative auto-regulation hold a duplicability advantage over transcription factors with no auto-regulation. CONCLUSION: Based on the analysis of transcriptional networks in E. coli and S. cerevisiae, there is no evidence that negative auto-regulation has contributed, on a genome-wide scale, to the variability in gene family sizes in these species. BioMed Central 2009-08-07 /pmc/articles/PMC2739200/ /pubmed/19664220 http://dx.doi.org/10.1186/1471-2148-9-193 Text en Copyright © 2009 Warnecke et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Warnecke, Tobias Wang, Guang-Zhong Lercher, Martin J Hurst, Laurence D Does negative auto-regulation increase gene duplicability? |
title | Does negative auto-regulation increase gene duplicability? |
title_full | Does negative auto-regulation increase gene duplicability? |
title_fullStr | Does negative auto-regulation increase gene duplicability? |
title_full_unstemmed | Does negative auto-regulation increase gene duplicability? |
title_short | Does negative auto-regulation increase gene duplicability? |
title_sort | does negative auto-regulation increase gene duplicability? |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739200/ https://www.ncbi.nlm.nih.gov/pubmed/19664220 http://dx.doi.org/10.1186/1471-2148-9-193 |
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