Reverse genetic characterization of the natural genomic deletion in SARS-Coronavirus strain Frankfurt-1 open reading frame 7b reveals an attenuating function of the 7b protein in-vitro and in-vivo

During the outbreak of SARS in 2002/3, a prototype virus was isolated from a patient in Frankfurt/Germany (strain Frankfurt-1). As opposed to all other SARS-Coronavirus strains, Frankfurt-1 has a 45-nucleotide deletion in the transmembrane domain of its ORF 7b protein. When over-expressed in HEK 293...

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Detalles Bibliográficos
Autores principales: Pfefferle, Susanne, Krähling, Verena, Ditt, Vanessa, Grywna, Klaus, Mühlberger, Elke, Drosten, Christian
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739521/
https://www.ncbi.nlm.nih.gov/pubmed/19698190
http://dx.doi.org/10.1186/1743-422X-6-131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739521/
https://www.ncbi.nlm.nih.gov/pubmed/19698190
http://dx.doi.org/10.1186/1743-422X-6-131

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