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Resolving deconvolution ambiguity in gene alternative splicing

BACKGROUND: For many gene structures it is impossible to resolve intensity data uniquely to establish abundances of splice variants. This was empirically noted by Wang et al. in which it was called a "degeneracy problem". The ambiguity results from an ill-posed problem where additional inf...

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Detalles Bibliográficos
Autores principales: She, Yiyuan, Hubbell, Earl, Wang, Hui
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739860/
https://www.ncbi.nlm.nih.gov/pubmed/19653895
http://dx.doi.org/10.1186/1471-2105-10-237