Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell lines

Gemcitabine (2′,2′-difluorodeoxycytidine) is a deoxycytidine analogue that is activated by deoxycytidine kinase (dCK) to its monophosphate and subsequently to its triphosphate dFdCTP, which is incorporated into both RNA and DNA, leading to DNA damage. Multidrug resistance (MDR) is characterised by a...

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Detalles Bibliográficos
Autores principales: Bergman, A M, Pinedo, H M, Talianidis, I, Veerman, G, Loves, W J P, van der Wilt, C L, Peters, G J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2003
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741118/
https://www.ncbi.nlm.nih.gov/pubmed/12799644
http://dx.doi.org/10.1038/sj.bjc.6601011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741118/
https://www.ncbi.nlm.nih.gov/pubmed/12799644
http://dx.doi.org/10.1038/sj.bjc.6601011

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