Cargando…

Alternative-Splicing in the Exon-10 Region of GABA(A) Receptor β(2) Subunit Gene: Relationships between Novel Isoforms and Psychotic Disorders

BACKGROUND: Non-coding single nucleotide polymorphisms (SNPs) in GABRB2, the gene for β(2)-subunit of gamma-aminobutyric acid type A (GABA(A)) receptor, have been associated with schizophrenia (SCZ) and quantitatively correlated to mRNA expression and alternative splicing. METHODS AND FINDINGS: Expr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Cunyou, Xu, Zhiwen, Wang, Feng, Chen, Jianhuan, Ng, Siu-Kin, Wong, Pak-Wing, Yu, Zhiliang, Pun, Frank W., Ren, Lihuan, Lo, Wing-Sze, Tsang, Shui-Ying, Xue, Hong
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741204/ https://www.ncbi.nlm.nih.gov/pubmed/19763268 http://dx.doi.org/10.1371/journal.pone.0006977

Ejemplares similares

Positive Selection within the Schizophrenia-Associated GABA(A) Receptor β(2) Gene
por: Lo, Wing-Sze, et al.
Publicado: (2007)

A Recombination Hotspot in a Schizophrenia-Associated Region of GABRB2
por: Ng, Siu-Kin, et al.
Publicado: (2010)

Social Cognitive Role of Schizophrenia Candidate Gene GABRB2
por: Tsang, Shui Ying, et al.
Publicado: (2013)

Two alternatively-spliced human nebulin isoforms with either exon 143 or exon 144 and their developmental regulation
por: Lam, Le Thanh, et al.
Publicado: (2018)

Influence of GABA(A) Receptor α Subunit Isoforms on the Benzodiazepine Binding Site
por: Lüscher, Benjamin P., et al.
Publicado: (2012)

Protein-Protein Interaction Inhibitor of SRPKs Alters the Splicing Isoforms of VEGF and Inhibits Angiogenesis
por: Li, Qingyun, et al.
Publicado: (2021)

Isoform-specific functions of an evolutionarily conserved 3 bp micro-exon alternatively spliced from another exon in Drosophila homothorax gene
por: Chang, Ling-Wen, et al.
Publicado: (2020)

An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells
por: Huang, Xiaofeng, et al.
Publicado: (2017)

The effects of midazolam and sevoflurane on the GABA(A) receptors with alternatively spliced variants of the γ2 subunit
por: Eom, Woosik, et al.
Publicado: (2011)

Effect of exonic splicing regulation on synonymous codon usage in alternatively spliced exons of Dscam
por: Takahashi, Aya
Publicado: (2009)

The Usage of Exon-Exon Splice Junctions for the Detection of Alternative Splicing using the REIDS model
por: Van Moerbeke, Marijke, et al.
Publicado: (2018)

The Landscapes of Full-Length Transcripts and Splice Isoforms as Well as Transposons Exonization in the Lepidopteran Model System, Bombyx mori
por: Dai, Zongrui, et al.
Publicado: (2021)

Predicting mutually exclusive spliced exons based on exon length, splice site and reading frame conservation, and exon sequence homology
por: Pillmann, Holger, et al.
Publicado: (2011)

α subunits in GABA(A) receptors are dispensable for GABA and diazepam action
por: Wongsamitkul, Nisa, et al.
Publicado: (2017)

Reduced splicing efficiency induced by synonymous substitutions may generate a substrate for natural selection of new splicing isoforms: the case of CFTR exon 12
por: Raponi, Michela, et al.
Publicado: (2007)

A Multi-Exon-Skipping Detection Assay Reveals Surprising Diversity of Splice Isoforms of Spinal Muscular Atrophy Genes
por: Singh, Natalia N., et al.
Publicado: (2012)

Blocking the 5′ splice site of exon 4 by a morpholino oligomer triggers APOL1 protein isoform switch
por: Cheatham, Amber M., et al.
Publicado: (2018)

PCBP1 inhibits the expression of oncogenic STAT3 isoform by targeting alternative splicing of STAT3 exon 23
por: Wang, Xiaole, et al.
Publicado: (2019)

Detection of orthologous exons and isoforms using EGIO
por: Ma, Jinfa, et al.
Publicado: (2022)

Computational Characterization of 3′ Splice Variants in the GFAP Isoform Family
por: Boyd, Sarah E., et al.
Publicado: (2012)

Splicing of designer exons informs a biophysical model for exon definition
por: Arias, Mauricio A., et al.
Publicado: (2015)

Detection of splice junctions from paired-end RNA-seq data by SpliceMap
por: Au, Kin Fai, et al.
Publicado: (2010)

Functional properties and evolutionary splicing constraints on a composite exonic regulatory element of splicing in CFTR exon 12
por: Haque, Ariful, et al.
Publicado: (2010)

RhoGEF9 splice isoforms influence neuronal maturation and synapse formation downstream of α2 GABA(A) receptors
por: de Groot, Claire, et al.
Publicado: (2017)

The exon 38-containing ARHGEF11 splice isoform is differentially expressed and is required for migration and growth in invasive breast cancer cells
por: Itoh, Masahiko, et al.
Publicado: (2017)

Alternative splicing of a single exon causes a major impact on the affinity of Caenorhabditis elegans tropomyosin isoforms for actin filaments
por: Ono, Shoichiro, et al.
Publicado: (2023)

Characterization of zebrafish GABA(A) receptor subunits
por: Sadamitsu, Kenichiro, et al.
Publicado: (2021)

The Emergence of Alternative 3′ and 5′ Splice Site Exons from Constitutive Exons
por: Koren, Eli, et al.
Publicado: (2007)

Identification of an exonic splicing silencer in exon 6A of the human VEGF gene
por: Wang, Rui, et al.
Publicado: (2009)

Prediction of alternatively skipped exons and splicing enhancers from exon junction arrays
por: Kechris, Katerina, et al.
Publicado: (2008)

Ligand-guided homology modelling of the GABA(B2) subunit of the GABA(B) receptor
por: Freyd, Thibaud, et al.
Publicado: (2017)

Long‐Read RNA Sequencing Identifies Alternative Splice Variants in Hepatocellular Carcinoma and Tumor‐Specific Isoforms
por: Chen, Hui, et al.
Publicado: (2019)

The contribution of δ subunit-containing GABA(A) receptors to phasic and tonic conductance changes in cerebellum, thalamus and neocortex
por: Ye, Zhiwen, et al.
Publicado: (2013)

Fast and Slow Inhibition in the Visual Thalamus Is Influenced by Allocating GABA(A) Receptors with Different γ Subunits
por: Ye, Zhiwen, et al.
Publicado: (2017)

Tau exon 10 alternative splicing and tauopathies
por: Liu, Fei, et al.
Publicado: (2008)

Recognition of Unknown Conserved Alternatively Spliced Exons
por: Ohler, Uwe, et al.
Publicado: (2005)

Syntrophin binds to an alternatively spliced exon of dystrophin
Publicado: (1995)

Evolution of Exon-Intron Structure and Alternative Splicing
por: Koralewski, Tomasz E., et al.
Publicado: (2011)

The evolution, impact and properties of exonic splice enhancers
por: Cáceres, Eva Fernández, et al.
Publicado: (2013)

The importance of DNA methylation of exons on alternative splicing
por: Shayevitch, Ronna, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_0klsl0bpruqiit5ntet86i3krp