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Transgene-specific host responses in cutaneous gene therapy: the role of cells expressing the transgene

A major issue in long-term gene therapy is host immune responses to therapeutic cells when transgene encodes a potential antigen. The nature of these responses depends on several factors including the type of cell and tissue expressing the transgene. Keratinocytes and fibroblasts, which are known to...

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Detalles Bibliográficos
Autores principales: Zhang, Zhenghua, Kuscu, Cem, Ghazizadeh, Soosan
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741533/
https://www.ncbi.nlm.nih.gov/pubmed/19440226
http://dx.doi.org/10.1038/gt.2009.67