In Vivo Turnover of Tau and APP Metabolites in the Brains of Wild-Type and Tg2576 Mice: Greater Stability of sAPP in the β-Amyloid Depositing Mice

The metabolism of the amyloid precursor protein (APP) and tau are central to the pathobiology of Alzheimer's disease (AD). We have examined the in vivo turnover of APP, secreted APP (sAPP), Aβ and tau in the wild-type and Tg2576 mouse brain using cycloheximide to block protein synthesis. In spi...

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Detalles Bibliográficos
Autores principales: Morales-Corraliza, Jose, Mazzella, Matthew J., Berger, Jason D., Diaz, Nicole S., Choi, Jennifer H. K., Levy, Efrat, Matsuoka, Yasuji, Planel, Emmanuel, Mathews, Paul M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741602/
https://www.ncbi.nlm.nih.gov/pubmed/19771166
http://dx.doi.org/10.1371/journal.pone.0007134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741602/
https://www.ncbi.nlm.nih.gov/pubmed/19771166
http://dx.doi.org/10.1371/journal.pone.0007134

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