Cargando…

In Vivo Turnover of Tau and APP Metabolites in the Brains of Wild-Type and Tg2576 Mice: Greater Stability of sAPP in the β-Amyloid Depositing Mice

The metabolism of the amyloid precursor protein (APP) and tau are central to the pathobiology of Alzheimer's disease (AD). We have examined the in vivo turnover of APP, secreted APP (sAPP), Aβ and tau in the wild-type and Tg2576 mouse brain using cycloheximide to block protein synthesis. In spi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morales-Corraliza, Jose, Mazzella, Matthew J., Berger, Jason D., Diaz, Nicole S., Choi, Jennifer H. K., Levy, Efrat, Matsuoka, Yasuji, Planel, Emmanuel, Mathews, Paul M.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741602/ https://www.ncbi.nlm.nih.gov/pubmed/19771166 http://dx.doi.org/10.1371/journal.pone.0007134

Ejemplares similares

The secreted APP ectodomain sAPPα, but not sAPPβ, protects neurons against Aβ oligomer-induced dendritic spine loss and increased tau phosphorylation
por: Tackenberg, Christian, et al.
Publicado: (2019)

Cerebrospinal Fluid Levels of sAPPα and sAPPβ in Lewy Body and Alzheimer's Disease: Clinical and Neurochemical Correlates
por: Mulugeta, Ezra, et al.
Publicado: (2011)

GFAP expression and social deficits in transgenic mice overexpressing human sAPPα
por: Bailey, Antoinette R, et al.
Publicado: (2013)

Effects of Heparin and Enoxaparin on APP Processing and Aβ Production in Primary Cortical Neurons from Tg2576 Mice
por: Cui, Hao, et al.
Publicado: (2011)

Leucine Carboxyl Methyltransferase 1 Overexpression Protects Against Cognitive and Electrophysiological Impairments in Tg2576 APP Transgenic Mice
por: Gnanaprakash, Madhumathi, et al.
Publicado: (2021)

Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice
por: Martín-Moreno, Ana María, et al.
Publicado: (2012)

Cell Type-Specific Human APP Transgene Expression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer’s Disease
por: Höfling, Corinna, et al.
Publicado: (2019)

Dysregulated Gut Homeostasis Observed Prior to the Accumulation of the Brain Amyloid-β in Tg2576 Mice
por: Honarpisheh, Pedram, et al.
Publicado: (2020)

Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway
por: Milosch, N, et al.
Publicado: (2014)

Autism as early neurodevelopmental disorder: evidence for an sAPPα-mediated anabolic pathway
por: Lahiri, Debomoy K., et al.
Publicado: (2013)

Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice
por: Rogers, Kathryn, et al.
Publicado: (2012)

Dysbiosis of Fecal Microbiota in Tg2576 Mice for Alzheimer’s Disease during Pathological Constipation
por: Kim, Ji-Eun, et al.
Publicado: (2022)

Age-Dependent Neuroplasticity Mechanisms in Alzheimer Tg2576 Mice Following Modulation of Brain Amyloid-β Levels
por: Lilja, Anna M., et al.
Publicado: (2013)

Ablation of the Locus Coeruleus Increases Oxidative Stress in Tg-2576 Transgenic but Not Wild-Type Mice
por: Hurko, Orest, et al.
Publicado: (2010)

Secreted Amyloid Precursor Protein Alpha (sAPPα Regulates the Cellular Proteome and Secretome of Mouse Primary Astrocytes
por: Peppercorn, Katie, et al.
Publicado: (2023)

Correction: Age-Dependent Neuroplasticity Mechanisms in Alzheimer Tg2576 Mice Following Modulation of Brain Amyloid-β Levels
por: Lilja, Anna M., et al.
Publicado: (2013)

A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice
por: Wolf, Andrea, et al.
Publicado: (2016)

Oat Extract Avenanthramide-C Reverses Hippocampal Long-Term Potentiation Decline in Tg2576 Mice
por: Lee, Yu-Young, et al.
Publicado: (2021)

Spared Piriform Cortical Single-Unit Odor Processing and Odor Discrimination in the Tg2576 Mouse Model of Alzheimer's Disease
por: Xu, Wenjin, et al.
Publicado: (2014)

S100a9 Knockdown Decreases the Memory Impairment and the Neuropathology in Tg2576 Mice, AD Animal Model
por: Ha, Tae-Young, et al.
Publicado: (2010)

Spatial training preserves associative memory capacity with augmentation of dendrite ramification and spine generation in Tg2576 mice
por: Jiang, Xia, et al.
Publicado: (2015)

Deletion of UCP1 in Tg2576 Mice Increases Body Temperature and Exacerbates Alzheimer’s Disease-Related Pathologies
por: Jung, Cha-Gyun, et al.
Publicado: (2023)

Caspr1 Facilitates sAPPα Production by Regulating α-Secretase ADAM9 in Brain Endothelial Cells
por: Tang, Shi-Yu, et al.
Publicado: (2020)

Defined astrocytic expression of human amyloid precursor protein in Tg2576 mouse brain
por: Heiland, Tina, et al.
Publicado: (2018)

A Novel Form of Compensation in the Tg2576 Amyloid Mouse Model of Alzheimer’s Disease
por: Somogyi, Attila, et al.
Publicado: (2016)

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid
por: Nichol, Kathryn E, et al.
Publicado: (2008)

Transcriptomic Analysis in the Hippocampus and Retina of Tg2576 AD Mice Reveals Defective Mitochondrial Oxidative Phosphorylation and Recovery by Tau 12A12mAb Treatment
por: Morello, Giovanna, et al.
Publicado: (2023)

Increased Secreted Amyloid Precursor Protein-α (sAPPα) in Severe Autism: Proposal of a Specific, Anabolic Pathway and Putative Biomarker
por: Ray, Balmiki, et al.
Publicado: (2011)

Increased Aβ pathology in aged Tg2576 mice born to mothers fed a high fat diet
por: Nizari, Shereen, et al.
Publicado: (2016)

Establishment of an Alzheimer’s disease model with latent herpesvirus infection using PS2 and Tg2576 double transgenic mice
por: Tanaka, Seiichi, et al.
Publicado: (2017)

Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation
por: Kim, Kyung-Ran, et al.
Publicado: (2021)

Exercise Training Results in Lower Amyloid Plaque Load and Greater Cognitive Function in an Intensity Dependent Manner in the Tg2576 Mouse Model of Alzheimer’s Disease
por: Thomas, Riya, et al.
Publicado: (2020)

S100A9 Knockout Decreases the Memory Impairment and Neuropathology in Crossbreed Mice of Tg2576 and S100A9 Knockout Mice Model
por: Kim, Hee Jin, et al.
Publicado: (2014)

Vulnerability of primary neurons derived from Tg2576 Alzheimer mice to oxygen and glucose deprivation: role of intraneuronal amyloid-β accumulation and astrocytes
por: Baldassarro, Vito Antonio, et al.
Publicado: (2017)

Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPP(swe) Mice Without Inducing Microhemorrhage
por: Villarreal, Stephanie, et al.
Publicado: (2017)

Amyloid Beta Pathology Exacerbates Weight Loss and Brain Cytokine Responses following Low-Dose Lipopolysaccharide in Aged Female Tg2576 Mice
por: Knopp, Rachel C., et al.
Publicado: (2022)

Regulation of the Soluble Amyloid Precursor Protein α (sAPPα) Levels by Acetylcholinesterase and Brain-Derived Neurotrophic Factor in Lung Cancer Cell Media
por: Al Khashali, Hind, et al.
Publicado: (2022)

Mannan-Abeta(28 )conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice
por: Petrushina, Irina, et al.
Publicado: (2008)

Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer’s Disease
por: Portbury, Stuart D., et al.
Publicado: (2017)

Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Aβ immunotherapy
por: Das, Pritam, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_u7gloq8kg0q5ihogj573n55760