Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

Oct4 exerts a dose-dependent dual action, as both a gatekeeper for stem cell pluripotency and in driving cells toward specific lineages. Here, we identify the molecular mechanism underlying this dual function. BMP2- or transgene-induced Oct4 up-regulation drives human embryonic and induced pluripote...

Descripción completa

Detalles Bibliográficos
Autores principales: Stefanovic, Sonia, Abboud, Nesrine, Désilets, Stéphanie, Nury, David, Cowan, Chad, Pucéat, Michel
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742180/
https://www.ncbi.nlm.nih.gov/pubmed/19736317
http://dx.doi.org/10.1083/jcb.200901040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742180/
https://www.ncbi.nlm.nih.gov/pubmed/19736317
http://dx.doi.org/10.1083/jcb.200901040

Ejemplares similares