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Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate

Oct4 exerts a dose-dependent dual action, as both a gatekeeper for stem cell pluripotency and in driving cells toward specific lineages. Here, we identify the molecular mechanism underlying this dual function. BMP2- or transgene-induced Oct4 up-regulation drives human embryonic and induced pluripote...

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Detalles Bibliográficos
Autores principales:	Stefanovic, Sonia, Abboud, Nesrine, Désilets, Stéphanie, Nury, David, Cowan, Chad, Pucéat, Michel
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2009
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742180/ https://www.ncbi.nlm.nih.gov/pubmed/19736317 http://dx.doi.org/10.1083/jcb.200901040

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