The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER

The US2 and US11 gene products of human cytomegalovirus promote viral evasion by hijacking the endoplasmic reticulum (ER)–associated degradation (ERAD) pathway. US2 and US11 initiate dislocation of newly translocated major histocompatibility complex class I (MHC I) from the ER to the cytosol for pro...

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Detalles Bibliográficos
Autores principales: Stagg, Helen R., Thomas, Mair, van den Boomen, Dick, Wiertz, Emmanuel J.H.J., Drabkin, Harry A., Gemmill, Robert M., Lehner, Paul J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742190/
https://www.ncbi.nlm.nih.gov/pubmed/19720873
http://dx.doi.org/10.1083/jcb.200906110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742190/
https://www.ncbi.nlm.nih.gov/pubmed/19720873
http://dx.doi.org/10.1083/jcb.200906110

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