Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator

We have carried out a cell-based screen aimed at discovering small molecules that activate p53 and have the potential to decrease tumor growth. Here, we describe one of our hit compounds, tenovin-1, along with a more water-soluble analog, tenovin-6. Via a yeast genetic screen, biochemical assays, an...

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Detalles Bibliográficos
Autores principales: Lain, Sonia, Hollick, Jonathan J., Campbell, Johanna, Staples, Oliver D., Higgins, Maureen, Aoubala, Mustapha, McCarthy, Anna, Appleyard, Virginia, Murray, Karen E., Baker, Lee, Thompson, Alastair, Mathers, Joanne, Holland, Stephen J., Stark, Michael J.R., Pass, Georgia, Woods, Julie, Lane, David P., Westwood, Nicholas J.
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742717/
https://www.ncbi.nlm.nih.gov/pubmed/18455128
http://dx.doi.org/10.1016/j.ccr.2008.03.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742717/
https://www.ncbi.nlm.nih.gov/pubmed/18455128
http://dx.doi.org/10.1016/j.ccr.2008.03.004

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