Oxidized α(1)-antitrypsin stimulates the release of monocyte chemotactic protein-1 from lung epithelial cells: potential role in emphysema

α(1)-Antitrypsin (AT) is a major elastase inhibitor within the lung. Oxidation of critical methionine residues in AT generates oxidized AT (Ox-AT), which has a greatly diminished ability to inhibit neutrophil elastase. This process may contribute to the pathogenesis of chronic obstructive pulmonary...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Zhenjun, Alam, Sam, Wang, Jicun, Sandstrom, Caroline S., Janciauskiene, Sabina, Mahadeva, Ravi
Formato: Texto
Lenguaje:English
Publicado: American Physiological Society 2009
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742802/
https://www.ncbi.nlm.nih.gov/pubmed/19525388
http://dx.doi.org/10.1152/ajplung.90373.2008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742802/
https://www.ncbi.nlm.nih.gov/pubmed/19525388
http://dx.doi.org/10.1152/ajplung.90373.2008

Ejemplares similares