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Oxidized α(1)-antitrypsin stimulates the release of monocyte chemotactic protein-1 from lung epithelial cells: potential role in emphysema

α(1)-Antitrypsin (AT) is a major elastase inhibitor within the lung. Oxidation of critical methionine residues in AT generates oxidized AT (Ox-AT), which has a greatly diminished ability to inhibit neutrophil elastase. This process may contribute to the pathogenesis of chronic obstructive pulmonary...

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Detalles Bibliográficos
Autores principales:	Li, Zhenjun, Alam, Sam, Wang, Jicun, Sandstrom, Caroline S., Janciauskiene, Sabina, Mahadeva, Ravi
Formato:	Texto
Lenguaje:	English
Publicado:	American Physiological Society 2009
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742802/ https://www.ncbi.nlm.nih.gov/pubmed/19525388 http://dx.doi.org/10.1152/ajplung.90373.2008

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