Comparison of DNA vaccines producing HIV-1 Gag and LAMP/Gag chimera in rhesus macaques reveals antigen-specific T-cell responses with distinct phenotypes

Optimized DNA expression vectors encoding the native HIV-1 Gag or a fusion of Gag with the lysosomal membrane associated protein 1 (LAMP) were compared for immunogenicity upon intramuscular DNA delivery in rhesus macaques. Both vaccines elicited CD4(+) T-cell responses, but with significant differen...

Descripción completa

Detalles Bibliográficos
Autores principales: Valentin, Antonio, Chikhlikar, Priya, Patel, Vainav, Rosati, Margherita, Maciel, Milton, Chang, Kern-Hee, Silvera, Peter, Felber, Barbara K., Pavlakis, George N., August, J. Thomas, Marques, Ernesto T.A.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743166/
https://www.ncbi.nlm.nih.gov/pubmed/19539586
http://dx.doi.org/10.1016/j.vaccine.2009.05.093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743166/
https://www.ncbi.nlm.nih.gov/pubmed/19539586
http://dx.doi.org/10.1016/j.vaccine.2009.05.093

Ejemplares similares