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Comparison of DNA vaccines producing HIV-1 Gag and LAMP/Gag chimera in rhesus macaques reveals antigen-specific T-cell responses with distinct phenotypes

Optimized DNA expression vectors encoding the native HIV-1 Gag or a fusion of Gag with the lysosomal membrane associated protein 1 (LAMP) were compared for immunogenicity upon intramuscular DNA delivery in rhesus macaques. Both vaccines elicited CD4(+) T-cell responses, but with significant differen...

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Detalles Bibliográficos
Autores principales:	Valentin, Antonio, Chikhlikar, Priya, Patel, Vainav, Rosati, Margherita, Maciel, Milton, Chang, Kern-Hee, Silvera, Peter, Felber, Barbara K., Pavlakis, George N., August, J. Thomas, Marques, Ernesto T.A.
Formato:	Texto
Lenguaje:	English
Publicado:	Elsevier Science 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743166/ https://www.ncbi.nlm.nih.gov/pubmed/19539586 http://dx.doi.org/10.1016/j.vaccine.2009.05.093

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