Cargando…
Ah receptor represses acute phase response gene expression without binding to its cognate response element
Repression of the NF-κB pathway has been extensively researched due to its pivotal role in inflammation. We investigated the potential of the aryl hydrocarbon receptor (AHR) to suppress NF-κB regulated gene expression, especially acute phase genes, such as serum amyloid A (Saa). Using AHR mutants, i...
Autores principales: | Patel, Rushang D., Murray, Iain A., Flaveny, Colin A., Kusnadi, Ann, Perdew, Gary H. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743259/ https://www.ncbi.nlm.nih.gov/pubmed/19333233 http://dx.doi.org/10.1038/labinvest.2009.24 |
Ejemplares similares
-
Ah Receptor Binding to its Cognate Response Element is Required for Dioxin-Mediated Toxicity
por: Perdew, Gary H.
Publicado: (2008) -
Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity
por: Muku, Gulsum E., et al.
Publicado: (2019) -
How Ah Receptor Ligand Specificity Became Important in Understanding Its Physiological Function
por: Murray, Iain A., et al.
Publicado: (2020) -
Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses
por: Muku, Gulsum E., et al.
Publicado: (2017) -
Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity
por: Dong, Fangcong, et al.
Publicado: (2020)