Persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion

Cellular senescence suppresses cancer by stably arresting the proliferation of damaged cells1. Paradoxically, senescent cells also secrete factors that alter tissue microenvironments2. The pathways regulating this secretion are unknown. We show that damaged human cells develop persistent chromatin l...

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Detalles Bibliográficos
Autores principales: Rodier, Francis, Coppé, Jean-Philippe, Patil, Christopher K., Hoeijmakers, Wieteke A. M., Muñoz, Denise P., Raza, Saba R., Freund, Adam, Campeau, Eric, Davalos, Albert R., Campisi, Judith
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743561/
https://www.ncbi.nlm.nih.gov/pubmed/19597488
http://dx.doi.org/10.1038/ncb1909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743561/
https://www.ncbi.nlm.nih.gov/pubmed/19597488
http://dx.doi.org/10.1038/ncb1909

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