Positive selection at codon 38 of the human KCNE1 (= minK) gene and sporadic absence of 38Ser-coding mRNAs in Gly38Ser heterozygotes

BACKGROUND: KCNE1 represents the regulatory beta-subunit of the slowly activating delayed rectifier potassium channel (IKs). Variants of KCNE1 have repeatedly been linked to the long-QT syndrome (LQTS), a disorder which predisposes to deafness, ventricular tachyarrhythmia, syncope, and sudden cardia...

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Detalles Bibliográficos
Autores principales: Herlyn, Holger, Zechner, Ulrich, Oswald, Franz, Pfeufer, Arne, Zischler, Hans, Haaf, Thomas
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743666/
https://www.ncbi.nlm.nih.gov/pubmed/19660109
http://dx.doi.org/10.1186/1471-2148-9-188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743666/
https://www.ncbi.nlm.nih.gov/pubmed/19660109
http://dx.doi.org/10.1186/1471-2148-9-188

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